Moebius Syndrome

Neurological Disorder

In The US: 1 in 50,000 to 1 in 500,000.

Also Called:
Moebius Sequence, Moebius Spectrum, Moebius Congenital Oculofacial Paralysis

Cleveland Clinic

Genetics Home Reference




Moebius Syndrome is suspected to be a random genetic trait that creates a neurological disorder rooted in a wide range of cranial nerves. The disorder can cause facial immobility, so that one is not able to make facial expressions like smiling or frowning. The muscle weakness- along with a cleft palate- can also lead to problems feeding and speaking. A person with Moebius Syndrome might also experience respiratory problems, visual impairments, sensory integration dysfunction, and more.

The symptoms of this disorder are apparent at birth. Infants are typically born with a small chin and mouth and an unusually shaped tongue. Dental abnormalities such as missing or misaligned teeth are also common. Other features include bone abnormalities in the hands and feet, weak muscle tone, and hearing loss. Affected children often experience a delayed development of motor skills and one third of them fall somewhere on the Autism Spectrum. Though it might slightly increase the risk of an intellectual disability, people with Moebius Syndrome are typically of normal intelligence.

Moebius Syndrome In The News

Leaving Them Smiling

Read More    published: 06/11/2018

The Happy Girl Who is Unable to SMILE: Rare Syndrome Means Surgery is the Only Hope Parents Have of Getting Rid of Their 3-Year-Old Girl's Scowl

Read More    published: 03/05/2018

Isle Disabled Teen Gets Invite From PM Theresa May to Visit 10 Downing Street

Read More    published: 12/11/2017

De Novo Mutations in PLXND1 and REV3L Cause Möbius Syndrome

Read More    published: 06/12/2015

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