Agenesis of the Corpus Callosum

Congenital Disorder of Brain

In The US: 0.5 to 70 in 10,000 births

Also Called:
Corpus Callosum or Agenesis

National Institute of Health

National Organization for Rare Disorders



Agenesis of the corpus callosum is complete or partial absence of the structure that connects the two hemispheres of the brain – the corpus callosum, which is the largest fibre tract in the central nervous system. It can occur as an isolated condition or in combination with other cerebral abnormalities. These include:

  • Arnold-Chiari malformation
  • Dandy-Walker syndrome
  • Andermann’s syndrome
  • Schizencephaly (clefts or deep divisions in brain tissue)
  • Holoprosencephaly (failure of the forebrain to divide into lobes)
  • Aicardi’s syndrome is found in girls alone – 300-500 cases worldwide

There is a spectrum of disability ranging from subtle to severe depending on associated brain abnormalities. Intelligence may be normal with mild compromise of skills requiring matching of visual patterns. But children with the most severe brain malformations may have low intelligence, seizures, hydrocephalus and spasticity.

Agenesis of the Corpus Callosum In The News

What you need to Know About Agenesis of the Corpus Callosum

Read More    published: 01/12/2015

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